High flow conditioned oxygen therapy for prevention of reintubation in critically ill patients at high risk for extubation failure: a multicenter randomised controlled trial
نویسندگان
چکیده
Introduction Critically ill mechanically ventilated patients are usually stratified in two levels according to the risk for reintubation. In low-risk patients high flow conditioned oxygen therapy (HFO) may reduce reintubation, whereas in high-risk patients non-invasive mechanical ventilation (NIMV) to prevent reintubation is gaining acceptance. However, data on the efficacy or safety of HFO in highrisk patients are lacking.
منابع مشابه
The OPERA trial - comparison of early nasal high flow oxygen therapy with standard care for prevention of postoperative hypoxemia after abdominal surgery: study protocol for a multicenter randomized controlled trial
BACKGROUND Respiratory support following postoperative extubation is of major importance to prevent hypoxemia and subsequent respiratory failure and reintubation. High-flow nasal cannula oxygen (HFNC) delivers a flow-dependent positive airway pressure and improves oxygenation by increasing end-expiratory lung volume. Whether application of HFNC may have therapeutic advantages over conventional ...
متن کاملHigh-flow oxygen therapy for extubation failure prevention in high-risk critically ill patients: a randomized multicenter trial
Introduction Extubation failure in critically ill patients has associated morbidity, but it cannot be safely predicted or avoided. Preventive NIMV has proved beneficial only in hypercapnic patients. We hypothesized that High-flow oxygen therapy may reduce postextubation respiratory failure due to gas humidification, avoidance of lung collapse by moderate PEEP, and work of breathing reduction by...
متن کاملHigh-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial
BACKGROUND Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure in low-risk patients. OBJECTIVE To demonstrate that HFNC reduces postextubation respiratory failure in high-risk non-hypercapnic patients compared with conventional oxygen. METHODS Randomized...
متن کاملSTUDY PROTOCOL Conditioned high-flow nasal cannula oxygen therapy for preventing reintubation in mechanically ventilated patients at low risk for extubation failure PRIMARY INVESTIGATOR
STUDY PROTOCOL Conditioned high-flow nasal cannula oxygen therapy for preventing reintubation in mechanically ventilated patients at low risk for extubation failure PRIMARY INVESTIGATOR Dr. Gonzalo Hernandez, MD PhD Critical Care Department of Hospital Virgen de la Salud Toledo, Spain CO-INVESTIGATORS Dr. Concepción Vaquero, MD. Hospital Universitario Ramón y Cajal, Madrid, Spain Dr. Paloma Gon...
متن کاملConditioned high-flow nasal cannula oxygen therapy for preventing reintubation in mechanically ventilated patients at low risk for extubation failure PRIMARY INVESTIGATOR
STUDY PROTOCOL Conditioned high-flow nasal cannula oxygen therapy for preventing reintubation in mechanically ventilated patients at low risk for extubation failure PRIMARY INVESTIGATOR Dr. Gonzalo Hernandez, MD PhD Critical Care Department of Hospital Virgen de la Salud Toledo, Spain CO-INVESTIGATORS Dr. Concepción Vaquero, MD. Hospital Universitario Ramón y Cajal, Madrid, Spain Dr. Paloma Gon...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015